Multiomics and physiological analyses evaluated how ferroptosis inhibition–modulated preclinical PAH. The impact of adeno-associated virus 1–mediated expression of the proferroptotic protein ACSL ...

Sample size estimation Serum GPX4, ACSL4, iron, Tf, and ferritin levels were used as the main outcome indexes for sample size calculation, and the ratio of sample size for each group was 1:1:1:1. We ...

We found that decreased GM3 induced VSMC ferroptosis through excessive holo-transferrin (holo-Tf) uptake and iron accumulation. Moreover, we established a mechanism by which GM3 bound to the ...

Researchers have discovered that ferroptosis also occurs in harmful contexts, killing healthy cells in patients with diseases like Parkinson’s, Alzheimer’s and Lou Gehrig’s disease. Ferroptosis can ...

We discovered that the transcription of PROM2 is regulated by heat shock factor 1 (HSF1). HSF1 inhibitors are available, and we observed that they sensitized a wide variety of resistant cancer cells ...

This work demonstrates that oncogenic activation of the PI3K-AKT-mTOR signaling pathway suppresses ferroptosis via the sterol regulatory element-binding protein-mediated lipogenesis, and that ...

Introduction Ferroptosis, a regulated non-apoptotic cell death, is characterized by overwhelming lipid peroxidation in an iron-dependent manner (Dixon et al., 2012; Stockwell et al., 2017). It was ...