The CEGR is composed of Cornell laboratories focused on understanding the mechanisms of gene regulation.

The aim of the first general part is to give the student an understanding of the main components of the eukaryotic transcription apparatus. Topics covered are: promoters, RNA polymerase II, general ...

Translational control (TC) is one the crucial steps that dictate gene expression and alter ... the role of eIF5B in translational regulation. This review recapitulates eIF5B’s regulatory roles in the ...

Gene regulation refers to the mechanisms that act to induce or repress the expression of a gene. These include structural and chemical changes to the genetic material, binding of proteins to ...

Many studies have used single-cell RNA sequencing (scRNA-seq) to infer gene regulatory networks (GRNs), which are crucial for ...

Human genes that encode proteins often contain non-coding segments known as introns. Removing introns is crucial for the proper expression of genetic information. Understanding how our cells ...

These two mechanisms seemed to function separately, each playing its own role in distinct stages of the gene regulation process. Perhaps that was a mistake. In a publication in the journal Cell ...

Gene silencing is a negative feedback mechanism that regulates gene expression to define cell fate and also regulates metabolism and gene expression throughout the life of an organism. In plants, gene ...

This achievement represents the completion of the global Sc2.0 project to create the world’s first synthetic eukaryotic genome ... team used specialized gene editing tools to identify and ...

An experimental gene therapy using modified blood stem cells helped five adults with severe hemophilia A attain therapeutic levels of clotting factor VIII (FVIII) to prevent and control bleeding, ...

Despite the established links between inflammation and cancer development, the effects of inflammatory signaling on cancer ...