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Parabilis’s ERG degrader uses Helicon technology to bind directly to the ERG protein and, through its attached E3 ligand, directs the ERG protein to the ubiquitin-proteasome pathway for degradation.

Both ERG (often present as a gene fusion, most commonly TMPRSS2:ERG) and PCA3 RNA are known to be overexpressed in PCa tissue 22, 23 and have been identified as biomarkers in post-DRE urine. 24 ...