Non-coding RNA transcribed from active enhancers, known as enhancer RNA (eRNA), is a critical element in gene regulation with a highly specific expression pattern in the regulatory networks of ...

Rugonersen, a novel RNA antisense oligonucleotide (ASO), has potential to be the first approved disease-modifying treatment for a disease affecting 500K individuals globally. Encouraging clinical ...

For at least 30 years scientists and drug developers bent on a sorely needed new class of therapeutics have been studying antisense RNA. The concept is deceptively simple: Binding of an ...

Summary: Researchers have identified a genetic mechanism that regulates behavioral adaptations to emotional experiences by forming R-loops, unique RNA:DNA structures that activate target genes.The ...

Much of the non-coding RNA is produced as the complementary strand to mRNA and is therefore referred to as antisense RNA (asRNA). Their function has been unclear for a long time.

They were also able to confirm several sets of known gene-enhancer pairs and generated a list of about 50,000 possible enhancer-gene pairs that they can now try to verify.

This suggested that this enhancer RNA may play a key role in mediating the clinical benefits of hammerhead FXR agonists, encouraging further research into its role and therapeutic value.

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