Without both doses, gene expression can go awry, and the resulting embryos can end up with abnormalities. This is what researchers have found in previous attempts to create mice with two dads.

During proestrus, eight to 12 weeks old CD1 female mice (Charles River, Germany) were injected with 5 IU of FSH (IBSA Pharma, Switzerland). Forty-eight hours later, the mice were treated with 5 IU hCG ...

Although mice with two dads have been born before, scientists used a completely different strategy in this study, which also provided insights into a reproductive mystery. In a process called ...

Using bi-paternal mouse embryos, the team used engineering methods like gene deletions and frameshift mutations - which create insertions or deletions in a DNA sequence to shift the way it is read ...

Genetic changes are a significant cause of infertility, impacting over 15% of the global population. TLE6, a major protein involved in early embryonic development, is known to affect female fertility.

All mice were maintained on a C57BL/6 background. Analysis was performed only after lines were crossed to C57BL/6 for at least three generations. The stage of mouse embryos was determined by taking ...

Prior studies have attempted to create mice from two male mice using stem cells. Found throughout the body in organs and tissues, these cells can develop into various cell types and are crucial for ...

They created a single-embryo atlas by comparing embryos from several mammalian species, including mouse, cow, pig, rabbit, and the non-human primate, rhesus macaque. Their findings were surprising ...

23, 2025 — Researchers have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice ... in a Pig Model of Heart Attacks Jan.

Scientists have attempted to create bi-paternal mice before, but the embryos developed only to a certain point and then stopped growing. The Chinese team focused on targeting imprinting genes ...