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EGCG 有望成为 HIV 入侵抑制剂:阻断 gp120-CD4 相互作用的新突破
研究人员综合运用多序列比对、系统发育分析、结构预测、药物吸收、分布、代谢、排泄(ADME)分析、分子对接研究和毒性分析等方法,发现表没食子儿茶素没食子酸酯(Epigallocatechin gallate,EGCG)有望成为阻断 gp120-CD4 相互作用的先导抑制剂,其结合亲和力达 ...
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