A new Drosophila collection of Parkinsonism models reveals early synaptic cholinergic projection neuron dysfunction, linking synaptic failure to later dopaminergic decline, highlighting a role for ...

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by the loss of dopaminergic neurons in the center of the brain that control movements. These neurons ...

Here, authors demonstrate that the Calb1+ subtype promotes locomotion, while the Kremen1+ subtype terminates ongoing movement by inhibiting the activity of Aldh1a1+ dopaminergic neurons via GABBR1 ...