NME posted a video leveraging the meme’s popularity as a hook, tilting it, “Cillian Murphy & Timothy Spall react to ‘disappointed Cillian Murphy meme’. “You’ve got to talk about ...

Thanks to that hilarious opening monologue from Conan O'Brien at the 2025 Oscars, we got the perfect new meme: John Lithgow looking disappointed. As O'Brien told the audience of Hollywood's best, if ...