Proteins form the structural and functional backbone of the cell, and any perturbation in their synthesis can disrupt normal cellular functions. The DNA blueprint is carefully read, transcribed, and ...

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, Yichang 443002, China ...

NON-enzymatic decarboxylation of α-amino-acids was tried many years ago by heating them above 200° C., often dissolved or dispersed in an inert solvent too. As the reactions are always exotherm ...

In most cases, a stop codon near the beginning of a gene would mean no functional protein gets made. It’s like halting the assembly of a car after installing just one bolt. The KEAP1 gene codes for a ...

Heyns and Pavel 1 reported on the pyrolytic decomposition of glycine in which small amounts ot other amino-acids (alanine, aspartic acid, α-aminobutyric acid) and other carboxylic acids (fumaric ...

The KEAP1 gene typically encodes a protein composed of more than 600 amino acids. A stop codon at position 15 would ordinarily halt translation near the beginning, producing only 14 amino acids.

Instead, the cellular machinery ignores it and keeps reading, inserting a different building block (amino acid) than was originally there ... The researchers compared KEAP1 genes from 196 mammal ...

Institut de Chimie de Clermont-Ferrand, Université Clermont Auvergne, CNRS, Clermont−Ferrand F-63000, France ...

They also highlight how the recoding of a de novo stop codon – a strategy thought restricted to viruses – can facilitate adaptation in vertebrates. Long prized for their speed and endurance ...