Finally, we continue to expand the actionable capabilities of our Generative Phosphoproteomics AP3 platform to enable us to ...

当这两个过程发生冲突时，分裂会暂停直至冲突解决。在此基础上，他们发现，阻断一种名为CHK1的重要检查点蛋白的活性，会导致实验室培养的含有ecDNA的肿瘤细胞死亡，小鼠肿瘤缩小。 热门推荐 ...

Event to be held via webcast on March 25, 2025 at 4:00 p.m. ET To highlight differentiated drug discovery capabilities with ...

Acrivon is currently advancing its lead candidate, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial ...

当这两个过程发生冲突时，分裂会（huì）暂停直至冲突（tū）解决。在此基础上，他们发现，阻断一种名（míng）为CHK1的（de）重要检查点蛋白的活性，会导致实验（yàn）室培（péi）养的含有ecDNA的肿瘤细胞死亡，小鼠肿瘤缩（suō）小（xiǎo）。 1、未♒️来15 ...

Combined, these findings show that CMA displays a broad targetability on multiple steps of the EMT process and indicate a substantial role of CMA in regulating the stability of pro-metastatic and ...

Centre for 3D models of Health and Disease, Division of Surgery and Interventional Science, University College London, London W1W 7TY, U.K. Centre for 3D models of Health and Disease, Division of ...

Figure 1 Mechanisms of radioresistance caused by DNA damage repair in NSCLC. Radiation induced DNA damage response can activate the DNA repair pathway, of which SSBs can be repaired through ATR/Chk1 ...

CEP135 associates with SAS6 to link it to CPAP. Checkpoint kinase 1 (CHK1) phosphorylates and inhibits cell division cycle 25 (CDC25) A/C, which is responsible for dephosphorylating and activating ...

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