Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases ...

Pulling proteins through a pore dissolves aggregates. Enzyme-like effects. A simpler form of the model also enables the researchers to see how enzyme-like “saturation” in each step affects the overall ...

Replacing the iron atom in Fe-porphyrin IX proteins with a noble-metal atom enables the creation of enzymes that catalyse reactions not catalysed by native Fe-enzymes or other metalloenzymes; this ...

A series of bacterial receptor proteins have been 'redesigned' by computer so that they bind molecules that are quite different from their natural ligands. The approach might be useful for ...

Up to three VCPIP1 molecules can bind to a single VCP hexamer, positioning their catalytic sites just below VCP’s central pore—right where unfolded proteins emerge. It’s a perfect arrangement: VCP ...

A research group have succeeded in greatly increasing the catalytic activity of Rubisco, the enzyme which fixes carbon from carbon dioxide in plant photosynthesis. The research team also ...

Their results showed that OGT played an important catalytic role, and it wasn't just potential structural properties that made it important to cell function. The study is published in the journal ...

Enzymes are amazing catalysts. These proteins are made of nothing more than a handful of Earth-abundant elements, and they promote a vast array of reactions, convert chemical energy to physical ...

In this image, the protein components of the ribosome are shown in yellow; its RNA is in grey. What should be obvious is that the image of rRNA as a scaffold for proteins has it exactly backwards.

Deubiquitinases (DUBs) are enzymes used by cells to trim protein modifications made from the protein ubiquitin, and thereby regulate proteins. Malfunctioning of DUBs could lead to diseases ...