New research uses AI to engineer enzymes with intricate active sites, expanding the possibilities for synthetic biocatalysts.

New research represents a notable step forward in designing enzymes from scratch. With their approach, the authors designed an enzyme that uses a covalent intermediate to catalyze a two-step reaction, ...

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This system enabled the authors to discover that the E3 ligase SCF–FBXO31, which is a complex composed of a catalytic module (comprising the proteins SKP1, CUL1 and RBX1) and a substrate ...

Loschmidt Laboratories, Department of Experimental Biology and RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno 602 00, Czech Republic ...

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The model demonstrated exceptional performance across key benchmarks, improving protein stability by up to 16.9% and optimizing catalytic activities and antibody-specific binding. "ProtET ...

The cause, they find, may be natural proteins of the immune system that normally target viruses by damaging their DNA. The proteins are called Apolipoprotein B mRNA editing catalytic proteins, or ...

Unfortunately, there isn't an enzyme for many reactions we would sorely like to catalyze—things like digesting plastics or ...

New research represents a notable step forward in designing enzymes from scratch. With their approach, the authors designed an enzyme that uses a ...