A compact RNA-guided enzyme, NovaIscB, derived from bacterial IscBs—evolutionary ancestors of Cas9—has been engineered for efficient, programmable genome editing in human cells.

The research article, “ Cryo-shocked tumor cells deliver CRISPR-Cas9 for lung cancer regression by synthetic lethality, ” was published in Science Advances. Cell-based gene editing delivery ...

The predicted orientation of the Cas9 protein on the AFM substrate is shown, and a simulated AFM image calculated in the scanning view perspective shows remarkable agreement with previous HS-AFM ...

The University of Bayreuth's Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 gene-editing tool to spiders. Following the genetic modification, the spiders ...

Discover how CRISPR-Cas9 technology is revolutionizing spider silk production with red fluorescent fibers and advancing genetic research.

An exon-skipping technique using dual single-guide RNA/Cas9 ribonucleoproteins targeted at 3 novel COL7A1 exons with pathogenic heterozygous mutations achieved exon deletion rates of up to 95%.

Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly ...