They extracted 4,241 amino acid residues from the fossil and zeroed in on five specific protein variants. Two of them, in the proteins ameloblastin (AMBN) and collagen alpha-2 (I) chain (COL1A2 ...

细胞类型注释与 CAFs 亚型鉴定：研究人员对 ER 阳性乳腺癌的单细胞 RNA 数据进行分析，共鉴定出 9 种主要细胞类型。进一步对 CAFs 进行深入研究，发现了 4 种不同的 CAFs 亚型，分别是 SOD3 (+) CAFs、COL1A2 (+) MMP1 (-) CAFs、RPS17 (+) CAFs 和 COL1A2 (+) MMP1 (+) CAFs。其中，MMP1 可作为区分 ...

研究揭示了 COL1A2 (+) MMP1 (-) 和 COL1A2 (+) MMP1 (+) CAFs 与不良预后的关系，以及它们在肿瘤微环境中的生物学功能和细胞间相互作用机制。 同时，发现的体细胞突变与 CAFs 浸润的关系，为预测 CAF 浸润提供了新的指标。

Background: Colorectal cancer (CRC) is surgically resectable and eminently screenable yet remains a lethal entity with high affinity to metastasise synchronously and metachronously. It has been ...

Brittle bone disease is usually caused by a defect or mutation in one of your genes for type 1 collagen, usually the COL1A1 or COL1A2 genes. Collagen is a protein that makes up the structural ...

这些在转基因小鼠模型中的发现表明， TET1/2/3酶特异性地存在于COL1A2真皮成纤维细胞区系中，是使VF+EFF出现和改善缺血肢体皮肤灌注的必要条件。

The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to setrusumab as a treatment to reduce fracture risk associated with osteogenesis imperfecta type I, III, or IV in ...

The Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to setrusumab as a treatment to reduce fracture risk associated with osteogenesis imperfecta type I, III, or IV ...

测定应在加终止液后 10 分钟以内进行。 m. 计算：COL1a2试剂盒；兔Ⅰ型胶原α2 (COL1α2)ELISA试剂盒根据浓度和OD值算出标准曲线的回归方程，建议用专用计算软件进行计算，推荐使用ELISAcalc进行计算，拟合模型选用logistic曲线（四参数）。 标曲示意图如下： ...

在 Col1a2-iCre小鼠（产品编号：C001528） 中，根据组织学形态结构分析，推测皮肤真皮层、心肌细胞之间、心脏瓣膜及心内膜、肺支气管、肺泡中发生Cre重组的细胞主要为成纤维细胞。 因此， Col1a2-iCre小鼠可用于靶向成纤维细胞的组织特异性研究。 工具鼠模型推荐 ...

Results: We identified 59 cases with PDGFB or PDGFD fusions: 55 COL1A1:: PDGFB, 3 EMILIN2:: PDGFD, and 1 COL1A2:: PDGFB cases. Of these, 51 were primary specimens and 8 metastatic. The patients ...