Objectives Metabolic changes are crucially involved in osteoclast development and may contribute to bone degradation in rheumatoid arthritis (RA). The enzyme aconitate decarboxylase 1 (Acod1) is known ...

As far back as 1873, Kölliker 1 observed the existence of osteoclasts in the periosteum of normal bone. Lacroix 2 also made several references to the presence of periosteal osteoclasts during ...

Correspondence to: Dr G J Gores Mayo Clinic College of Medicine, 200 First St SW, Rochester, Minnesota 55905, USA; gores.gregorymayo.edu ...

BPs promote osteoprotegerin secretion by osteoblasts, and their mechanism of action to inhibit bone resorption is mainly twofold. On the one hand, they regulate osteoclast proliferation, ...