EurekAlert!5d
Unraveling the role of the Wnt pathway in hepatocellular carcinoma: From molecular mechanisms to therapeutic implications
Hepatocellular carcinoma (HCC) is one of the deadliest malignant tumors in the world, and its incidence and mortality have ...
Nature5y
Armadillo takes the APC shuttle
Combined efforts of developmental biologists and cancer geneticists have outlined the canonical Wnt/Wingless (Wg) signalling pathway ... catenin in colon-cancer cells. Figure 1: Map of the APC ...
Medscape5d
Mechanisms of Disease: From Stem Cells to Colorectal Cancer
Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274. The WNT signaling pathway. (A) In the absence of WNT binding to frizzled, dishevelled remains unactivated and β-catenin is targeted for ...