Recently, abnormal expression of long noncoding RNAs (lncRNAs) was identified as a vital regulator involved in the initiation and development of HCC. Activation of the Wnt/β-catenin pathway has been ...

Confocal microscopy, reporter assay, immunoprecipitation, immunoblotting, ion flux assays and holographic imaging were used to determine effects on colon cancer cells. Conclusions These data identify ...

vanderbilt.edu Design Tff1-knockout (Tff1-KO) mice, immunohistochemistry, luciferase reporter, qRT-PCR, immunoblot, and phosphatase assays were used to examine the role of TFF1 on β-catenin signalling ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274. The WNT signaling pathway. (A) In the absence of WNT binding to frizzled, dishevelled remains unactivated and β-catenin is targeted for ...

On the other hand, activation of the Wnt/β-catenin pathway or reexpression of stem/precursor cell markers, i.e., shh, could explain the abnormal proliferation leading to the formation of an adenoma.

With the new year bringing the curtain down on the most used version of Windows, APC explores where consumers and businesses should head next. In this feature, we’ll systematically go through ...

Methods Inflammatory markers and EMT-related molecules were evaluated in NP models using adenomatosis polyposis coli (Apc) Min/+ mice with activated Wnt signaling and NP models treated with Wnt ...

Colorectal cancer (CRC) is a major health problem, with an alarming increase of early-onset CRC (EO-CRC) cases among individuals under 50 years of age. This trend shows the urgent need for ...