Vancomycin is a glycopeptide antibiotic that was introduced in 1956 to treat S. aureus infections, but was quickly overshadowed by the less toxic semisynthetic penicillins, such as methicillin ...

FOLLOWING on the isolation in these Laboratories of 6-aminopenicillanic acid1, we have used it to synthesize many novel penicillins, with particular emphasis on structures which resist ...

Because of the physiological changes in the SCI population, differences in drug pharmacokinetic parameters, and difficulties in assessing renal function in these patients, dosing aminoglycosides ...

Penicillinase-Resistant Penicillins The introduction of methicillin in September, I960,77 , 78 provided a drug with a unique property not found in earlier penicillins — namely, resistance to ...

Nature - A Survey of New Penicillins. Fleming, A., Brit. J. Exp. Path., 10, 226 (1929). CAS PubMed Central Google Scholar . Abraham, E. P., Chain, E., Fletcher, C. M ...

2030 patients were screened between Oct 5, 2016, and Jan 23, 2020, of whom 171 were randomly assigned to the de-escalation group and 173 to the control group. 164 (50%) patients in the de-escalation ...

Other drugs that can cause hypokalemia include amphotericin B, antipseudomonal penicillins (such as carbenicillin) and high-dose penicillin. Finally, hypokalemia is observed in both acute and chronic ...

Data analysis showed the prevalence of P aeruginosa in patients with COPD with scores of 0 and 1 point was 2% and 5%, respectively, whereas the prevalence was 20% in those with scores of 2 points and ...

Researchers recently found no differences in the number of antipseudomonal classes administered in primary or sensitivity analyses in patients with cystic fibrosis (CF) regarding lung function, ...

Patients were treated with either 2 (n=2123) or 1 (n=455) intravenous antipseudomonal antibiotic. The median age of patients was 16.1 years (interquartile range [IQR], 13.3-18.0) for those receiving 2 ...