Nat Clin Pract Gastroenterol Hepatol. 2006;3(5):267-274. An adaptation of the Vogelstein adenoma:carcinoma sequence. The acquisition of a mutation (or 'hit') in a stem cell within a crypt ...

Figure 2: Contrasting effects of telomere shortening on tumor formation in Apc Min mice. Figure 5: Telomere dysfunction peaks at the adenoma-carcinoma transition in human colorectal carcinogenesis.

Colorectal cancer is an excellent example of the complex multistage process of carcinogenesis. Most colorectal cancers develop from adenomas (benign tumours also called polyps) in what is often ...

The evaluation of short- and long-term risk for developing cancer in patients with ... KRAS mutation Any polyp 4 CIMP negative, MSS Adenoma-carcinoma sequence 5 (Lynch syndrome) CIMP negative ...

The approach requires balance, however. There is the risk of increased AEs, as well as financial toxicity. Friedlander shared ...