UCLA professor of integrative biology and physiology David Walker, PhD, and colleagues, in addition showed that tweaking a few specific genes in aging fruit flies’ neurons prevented this F-actin ...

As they had found when studying cell migration, disrupting SETD2's ability to methylate actin at lysine-68 caused defects in actin polymerization. In autophagy, disrupted actin polymerization ...

In contrast to the well-characterized configurations of actin filaments in NKs during the lytic process, there is a gap of knowledge regarding the organization and role of the tumor cell actin ...

On the other hand, autophagy was recently shown to involve actin, but the mechanism was unknown. The Penn scientists connected these observations and hypothesized that possibly WHAMM could link ...

Not only have researchers identified how a common cellular protein affects aging, but they’ve tweaked the genes that produce it in fruit flies, extending healthy lifespan by 25% to 30%. The ...

The new study shows that preventing F-actin accumulation led to much more active autophagy in the brains of aged fruit flies.

Autophagy is the body’s way of cleaning out damaged cells, in order to regenerate newer, healthier cells. It allows your body to remove the dysfunctional cells.

Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste ...