Protein translocation is an essential, nano-scale dynamic process that facilitates the movement of proteins across cellular ...

In nature, this is achieved by a machinery of proteins: motor proteins powered by chemical energy from ATP hydrolysis pull together a ring of filaments of the protein actin. Adenosine triphosphate ...

The conformation of ABC transporters that is catalytically competent for nucleotide hydrolysis involves the binding of an ATP molecule between conserved sequence motifs at the interface between ...

Kinesins contain a conserved motor domain for ATP hydrolysis and microtubule binding, and divergent non-motor domains for family-specific regulatory mechanisms and functions. The regulation of ...

The motor domain contains the catalytic site for ATP hydrolysis and the actin or microtubule-binding site. The neck region acts as a lever arm, amplifying the small conformational changes generated by ...