Background Current treatments with tyrosine kinase inhibitors and immune checkpoint inhibitors have limited efficacy for ...

Background The determinants of the response to checkpoint immunotherapy in hepatocellular carcinoma (HCC) remain poorly understood. The organisation of the immune response in the tumour ...

The gut microbiome is essential for human health and disease, acting in a symbiotic relationship with its host. In chronic ...

Background Endoscopic procedures are a notable source of medical waste, contributing significantly to environmental pollution. Prior studies report 0.5–3.0 kg of waste per procedure—compared with just ...

A 24-year-old man presented with a 7-year history of recurrent melena, acutely worsening 3 days prior. He had undergone ...

Objective To determine whether new users of proton pump inhibitors (PPIs) are at an increased risk of gastric cancer compared with new users of histamine-2 receptor antagonists (H2RAs). Design Using ...

Correspondence to Professor Hua Peng, Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China; hpeng{at}ibp.ac.cn; Professor Yang-Xin Fu, ...

Correspondence to Fons F van den Berg, Department of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam 1105 AZ, The Netherlands; f.f.vandenberg{at}amsterdamumc.nl Objective The gut microbiota ...

Faecal immunochemical testing (FIT) has a high sensitivity for the detection of colorectal cancer (CRC). In a symptomatic population FIT may identify those patients who require colorectal ...

Background Genomic screening uncovered interferon-gamma (IFNγ) pathway defects in tumours refractory to immune checkpoint blockade (ICB). However, its non-mutational regulation and reversibility for ...

Objective Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis—Microbiome As Predictor of ...

Objective Multiple clinical similarities exist between IgG4-related sclerosing cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC), and while gut dysbiosis has been extensively studied in ...