The poly-A tail is a long chain of adenine nucleotides that is added to a messenger RNA (mRNA) molecule during RNA processing to increase the stability of the molecule. Immediately after a gene in ...

Get Instant Summarized Text (Gist) A mechanism regulating mRNA poly(A) tail length in early embryos has been identified, involving the protein MARTRE1, which inhibits the CCR4-NOT complex. MARTRE1 ...

Regulation of the poly(A) tail is essential for selective protein translation in early embryos. However, the mechanisms that determine and maintain the length of maternal mRNA poly(A) tails remain ...

An evolutionarily conserved mRNA-degradation pathway is initiated by the removal of the 3′ poly(A) tail. This disrupts the translation initiation complex and provides degradative enzymes with ...