The properties of the different IgG isotypes should be considered in developing therapeutic antibodies. To address this problem, antibody engineers introduced a serine-to-proline substitution that ...

Immunoglobulin G (IgG) is the dominant antibody isotype in human serum and appears in four variants: IgG1, IgG2, IgG3 and IgG4. Given their critical role in the immune system, IgGs are a major ...