So far, only two (co)chaperone proteins have been studied in relation to GC resistance in ALL. Kojika et al 9 reported aberrant HSP-90 protein expression (80 and 160 kDa instead of 90 and 180 kDa ...

An unusual molecular chaperone A peculiarity occurs as soon as the chaperone HSP-90 ("Heat Shock Protein 90") encounters tau. "Normally, it is the job of chaperones to bring newly produced ...

An unusual molecular chaperone A peculiarity occurs as soon as the chaperone HSP-90 ("Heat Shock Protein 90") encounters tau. "Normally, it is the job of chaperones to bring newly produced ...

Nature Cell Biology - Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability Skip to main content Thank you for visiting nature.com.

Hsp70. The Hsp70 chaperone proteins are folding catalysts that assist in many kinds of folding processes such as refolding or misfolding of aggregated proteins, and folding and assembling of new ...

Stress‐inducible phosphoprotein 1 (STI1; STIP1; HOP) is a co‐chaperone that simultaneously interacts with Hsp70 and Hsp90, but whose function in vivo remains poorly understood. We combined in‐depth ...

MBT-C101 is a selective, potentially first-in-class potent HSP90 chaperone-mediated degrader of PI3Kα, for the treatment of breast cancer. It was developed by Magicbullet Therapeutics Inc. using the ...