But as the probe comes into contact with HO-1, the enzyme breaks a bond connecting these two compartments, and causes a build up of the fluorescent molecules in the donor compartment.

Fluorogenic probe to detect enzyme linked to early stage of Alzheimer’s . Indian Institute of Science (IISc) Journal Analytical Chemistry DOI 10.1021/acs.analchem.3c00099. Keywords ...

The team's probe works by detecting an enzyme that is released in large quantities during IPHs, called heme oxygenase-1 (HO-1). Previous attempts to screen for HO-1 have been unreliable and cannot ...

The probe combines a fluorophore and a zinc-binding region. It fluoresces only when it binds to both zinc atoms in the enzyme active site. In the presence of inhibitors that block the active site ...

A fluorescent probe lights up the enzyme beta-galactosidase in a cell culture. The glowing probe-enzyme combination could make tumors fluoresce, allowing surgeons to cut away cancer while leaving ...

We have developed a general experimental strategy that enables the quantitative detection of dynamic protein–protein interactions in intact living cells, based on protein-fragment ...

All the latest science news on fluorescent probe from Phys.org. Find the latest news, advancements, and breakthroughs. Topics. ... Therefore, tracking enzyme activity is a valuable strategy for ...

Elena A. Goun of the University of Missouri and coworkers have developed a bioluminescent probe to measure BSH activity in a variety of settings, including in bacteria, fecal samples, and live ...

Neutrons probe oxygen-generating enzyme for a greener approach to clean water. ScienceDaily. Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2017 / 11 / 171113195004.htm.

In another experiment, in mice, the team used the probe to test the ability of different types of prebiotic supplement — inulin and fructo-oligosaccharides (FOSs) — to boost the production of BSH.

After a primary tumor is treated, cancer stem cells may still lurk in the body, ready to metastasize and cause a recurrence of the cancer in a form that's more aggressive and resistant to treatment.

It is now possible to obtain three-dimensional, high-resolution images of enzyme activity in tissue samples or whole organs—thanks to probe molecules that anchor fluorescent dyes within tissue ...