NSAIDs act by inhibiting the activity of the enzyme cyclo-oxygenase (COX), and thereby prostaglandin and thromboxane production. [1] COX exists as 2 isoforms, COX-1 and COX-2.

nimesulide is a weak competitive inhibitor of COX-1 but a potent time-dependent inhibitor of COX-2, whereas celecoxib exhibits slow competitive binding and, at higher concentrations, binds ...

Celebrex is a selective COX-2 inhibitor that targets inflammation with fewer gastrointestinal side effects, whereas ibuprofen ...

The third, Celebrex, is still available ... Most NSAIDs affect levels of both Cox-1 and Cox-2 enzymes. Cox-2 inhibitors only block the Cox-2 enzyme. So these drugs don't affect the prostaglandins ...

That's because most NSAIDs, like ibuprofen, are COX-1 inhibitors ... To protect your stomach, you could consider a COX-2 inhibitor like Celebrex because it blocks inflammation while keeping ...

Celebrex belongs to the Cox-2 inhibitors, painkiller family. Vioxx and Bextra are the other members that are no longer available in the market due to their connection with heart disease.