Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and ...

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Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...

A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an adolescent with progressive SETTLE tumor. Target identification combined with pre ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. This longitudinal single-cell transcriptome ...

How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role for transcription factor HAND1 in mesoderm patterning and the specification ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Widespread control of gene expression through ...

Using genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. During somatosensory neurogenesis, neurons are ...

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The effect of saccharin on the microbiome has received much attention, but its impact on pathogenic bacterial species is less clear. This study reports the potential of saccharin to be developed as a ...