Top-down proteomics: Intact proteins are ionized and analyzed directly, allowing for the study of proteoforms and ...

Authors can choose to publish the referee reports, editorial correspondence and decision letters alongside their paper – and more than 95% of our authors do. Our editors will respect the exclusion of ...

Cysts, fibrosis, and tubular degeneration form the typical triad of pathologies leading to the gradual decline in kidney ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to ...

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Malaria parasites undergo an extensive metamorphosis after invasion of erythrocytes. This induces an increase in the surface ...

A precision medicine workflow integrating proteomics and personalized xenograft models was developed and applied to an adolescent with progressive SETTLE tumor. Target identification combined with pre ...

Using genetically predicted metabolic reaction fluxes, the authors identify reactions that can amplify or buffer the effect ...

How cardiac cell fates are specified during heart development remains elusive. This study identifies a level-dependent role for transcription factor HAND1 in mesoderm patterning and the specification ...

Espin induces abundant filopodia formation at the leading edge and along the sides, exerting force for cells migrating in ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Widespread control of gene expression through ...

In Davidi et al , we performed a high-throughput spectrophotometric assay on over 100 rubiscos. The kinetic parameters of the ...