• (a) 时间依赖性细胞摄取效率：随着时间的推移，siRNA共轭物的细胞摄取效率的变化。 • (b) 通过添加NaN3（30 mM）和4°C孵育抑制细胞摄取：在4°C ...

为探究 ago-sirna 复合物如何克服结构限制实现高效靶标切割，研究人员开展了人类 ago-sirna 复合物与不同长度靶 rna 结合的冷冻电镜研究。结果揭示了其靶标识别和切割的逐步机制，为理解 ago 和 piwi 蛋白的作用方式提供了新视角。

一场医学革命正在到来。 过去，小干扰RNA（siRNA）疗法停留在罕见病领域，导致市场空间受限。然而，诺华长效降血脂药Inclisiran的获批打破了这一 ...

AbbVie has signed a collaboration and licensing agreement with US-based ADARx Pharmaceuticals, committing $335m upfront to access its small interfering RNA (siRNA) platform. The partnership gives ...

With a different spray to tackle each problem, it represents good value for money at £14.99. Peppermint oil is used as a natural rodent repellent because mice dislike its strong, menthol scent.

Functional cure of chronic hepatitis B (CHB) remains a major clinical challenge. Current therapies—including nucleos(t)ide analogs, interferon, siRNA, and therapeutic vaccines—often fail to ...

More information: Rita C. Acúrcio et al, Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 ...

Homeowners with spray foam insulation are struggling to sell or remortgage as some major lenders are rejecting properties with it fitted, the BBC has found. A quarter of the UK's biggest mortgage ...

Two police officers joked about using a full can of Pava spray on a 92-year-old care home resident who had just been tasered and arrested, a court has heard.. Body-worn video footage of officers ...

Dear Heloise: May I share some spray-painting tips? We love to rejuvenate our yard seesaws with spray paint as rust and fading from the sun does happen over time. Prevention is the best medicine.

Clinical Trial Growth & Future Outlook: Analysis of the 150+ industry-sponsored siRNA clinical trials conducted between 2020 and 2024, with a 79.5% CAGR reflecting significant industry investment.

Sirius Therapeutics today announced that preliminary data from its Phase 1 clinical trial of SRSD107, a next generation siRNA therapeutic under clinic ...