The double-stranded RNA is processed by an RNase III family enzyme Dicer, resulting in the generation of an siRNA, a 21–23-nucleotide (nt) RNA duplex, composed of a 19-mer sequence with ...

In a collaborative study with the David Bartel lab (MIT), we demonstrated that budding yeast Dicers initiate processing in the interior and work outwards in contrast to canonical Dicers, which ...

Pre-miRNAs are transported to the cytoplasm by Exportin 5 and are processed into miRNA:miRNA* duplexes by Dicer. Dicer also processes long dsRNA molecules into small interfering RNA (siRNA ...

The discovery of siRNA and its role in RNAi was a groundbreaking finding in the field of molecular biology. In 1998, Andrew Fire and Craig Mello published a seminal paper describing the phenomenon of ...

The platform is specifically intended for the delivery of duplex RNA, such as siRNA, into the central nervous system (CNS) via intrathecal injection. The therapy also improved motor function and ...