Additionally, the study's findings may broadly influence drug discovery efforts targeting RNA-binding proteins. "Our structural insights into ADAR1 provide a solid foundation for designing small ...

"It likely sequesters other RNA-binding proteins, creating an even more toxic environment for cancer cells." Further studies will refine ASO-based therapies and explore their delivery to tumors.

When the coat proteins come into contact after binding the RNA hairpins, these luciferase fragments, along with the enzyme’s substrate furimazine, join together—and the probe lights up.

The research work forms the potential basis for more complex RNA machinery. One major challenge in constructing synthetic cells is manufacturing proteins, which are responsible for nearly all ...

RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, portions of the RNA that don't code for proteins, called introns ...

Messenger RNA (mRNA) is the genetic blueprint that tells cells how to produce proteins. It plays a vital ... This modification prevents TRIM25 from binding to mRNA, enhancing the stability and ...

Subscribe for FREE RNA molecules carry instructions from DNA for making proteins that carry out much of the work of living cells. Knowing where these molecules are located in complex tissues is a ...