The biogenesis of miRNAs involves a multi-step process that begins in the nucleus and ... The pre-miRNAs are exported to the cytoplasm, where they are further cleaved by the Dicer enzyme to generate ...

Eukaryotes have evolved small-RNA-guided regulatory systems for the control of RNA transcripts, chromatin, genome content and invasive agents. Specialized silencing systems evolved in eukaryotic ...

In addition, exosome delivery systems struggle with preserving bioactivity and maintaining adaptable miRNA cargoes throughout ... for efficient biogenesis of exosomes. Through the synergistic ...