In many cellular settings, the first regulatory process (see figure, step 1) involves the de-repression of the mTOR Ser/Thr kinase, which inhibits autophagy by phosphorylating autophagy protein-13 ...

In 2000, it was suggested to me that “Autophagy will be the wave of the future; it will become the new apoptosis.” Few people would have agreed at the time, but this statement turned out to be ...

Microplastics (MPs) are widely distributed environmental pollutants around the world. Although studies have demonstrated that MPs have adverse effects on human health, the relationship between MPs and ...

Combination treatment with ibrilatazar and chemotherapy has demonstrated “promising efficacy and safety” in patients with advanced squamous non-small cell lung cancer (NSCLC), according to researchers ...

Suppressing mTOR seems to weaken inflammation and accelerate autophagy, a process of purging damaged materials from cells. Chronic inflammation is associated with diabetes, heart disease and ...

It’s believed that the drug inhibits a biological pathway called the mTOR complex, which boosts cellular health by decreasing inflammation and helping autophagy, the process that clears junk ...