These findings support the hypothesis that strong secondary structure at the 5′ end of an mRNA blocks ribosome binding and delays translation initiation. To test this idea, the authors added an ...

Recent publications analyzing the relationship between local free energy and siRNA efficiency 4,5 have demonstrated that mRNA target site secondary structure is of great importance for siRNA ...

tRNAs have a distinct cloverleaf secondary structure and an L-shaped tertiary structure. The cloverleaf structure is formed by the folding of the single-stranded tRNA molecule, which is typically ...