During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective ...

image: Poly(A) tail-mediated maternal mRNA remodeling during human oocyte-to-embryo transition view more . Credit: IGDB. Human development starts from the fertilization of a fully matured oocyte.

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

“Downstream processing for mRNA manufacturing is currently too complex, but simplifying by using precipitation, for example, could help a lot,” she says. The new process aims to precipitate ...

In cultured human neurons, α-synuclein slowed mRNA degradation by physically interacting with key P-body proteins tasked with dismantling transcripts. In postmortem tissue from human frontal cortex, ...

A team of researchers has observed sperm mRNA in newly fertilized eggs, according to a paper published in the May 13 Nature, in a finding that provides alternative explanations for mammalian ...