RNA methylation. Of the ~100 post-transcriptional chemical modifications to RNA known, N 6-methyladenosine (m 6 A) is the most prevalent modification in mRNA. Although described over 40 years ago, ...

image: Poly(A) tail-mediated maternal mRNA remodeling during human oocyte-to-embryo transition view more . Credit: IGDB. Human development starts from the fertilization of a fully matured oocyte.

During the oocyte-to-embryo transition (OET), the length of the mRNA poly(A) tail is closely linked to its translational efficiency. Regulation of the poly(A) tail is essential for selective ...

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

“Downstream processing for mRNA manufacturing is currently too complex, but simplifying by using precipitation, for example, could help a lot,” she says. The new process aims to precipitate ...

In cultured human neurons, α-synuclein slowed mRNA degradation by physically interacting with key P-body proteins tasked with dismantling transcripts. In postmortem tissue from human frontal cortex, ...