2025年，全球mRNA疫苗累计接种已超百亿剂次，其高效性与安全性彻底改写了传染病防控的格局。从新冠疫苗到癌症治疗，mRNA技术正以惊人的速度渗透医学领域。然而，回溯至2005年，科学家Karikó团队首次发现，将mRNA中的尿苷（U）替换为假尿苷（Ψ），可显著降低免疫原性，这一发现成为mRNA疗法的“阿基米德支点”。但为何Ψ-RNA能逃避免疫系统的安检？

本文聚焦癌症 mRNA 疫苗，阐述其作为新兴免疫疗法，在临床应用中的进展与挑战。介绍了优化策略、作用机制、临床试验成果及联合疗法，分析现存问题并展望未来，为癌症免疫治疗研究提供全面参考。

在基因表达调控的研究中，研究人员聚焦于 mRNA 上的化学修饰。为探究 N6- 甲基腺苷（m6A）和 tRNA 修饰在 mRNA 衰变中的作用，他们开展相关研究。结果发现二者相互作用调控 mRNA 衰变，且该系统与癌症相关。这为理解转录后基因调控机制提供新视角。

The mRNA metabolism passively shapes the levels of an mRNA modification called m6A within a steady-state cell and upon stress.

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

In this GEN webinar, Scott Alderucci will discuss ways of leveraging new technologies and experimental design for an optimized, tailored approach to mRNA therapy development.

In this experiment, they ran the TFF at a capacity load of ∼19 g/m 2, less than 2.5 psi trans-membrane pressure, and feed flux of 300 L/m 2 /h (LMH), corresponding to a shear rate of 1594 s −1 ...

That’s because, for mRNA-based Covid-19 vaccines like those developed by Pfizer/BioNTech and Moderna, a shot in the arm did the trick. But in cases where mRNA is harnessed for other uses ...

The promise of mRNA technology seemed boundless after the success of the coronavirus vaccines, but Robert F. Kennedy Jr. has singled it out for scrutiny, clouding its prospects.

China's CanSino Biologics Inc has entered "test production phase" for its COVID-19 mRNA booster vaccine, the company said in a post on its social media account late on Thursday.

Moderna has said that it was keen to sell its mRNA vaccine to China but the company and its foreign peers have so far been kept out as Beijing has insisted on using only Chinese-made COVID-19 ...