Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing ...

The N-terminal ATP-dependent ligase domain belongs to the covalent nucleotidyltransferase enzyme superfamily that includes classic RNA/DNA ligases and mRNA capping enzymes. We’ve shown that: (i) each ...

Structure of the yeast 12-subunit nuclear exosome We pioneered methods to reconstitute eukaryotic RNA exosomes from budding yeast and human. Early efforts determined the activities of yeast and human ...

Yeast RNA, in contrast, does not precipitate at either ionic strength, as shown in Figure 2. As practical applications will usually involve at least a modest ionic strength, the concentration of ...

but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo. I suggest that ∼90% of Pol II initiation events in yeast represent transcriptional noise ...

Ribosomal translation is the process by which cells synthesize proteins based on the genetic instructions encoded in messenger RNA. It is essential ... known as Brewer's yeast—at near-atomic ...