The structure of the PP7 bacteriophage coat protein revealed a mode of RNA binding that is distinct from that of the well-characterized MS2 coat protein, suggesting new orthogonal systems for RNA ...

siRNAs loaded in an Argonaute protein then target complementary single-stranded RNA (ssRNA) to guide specific gene silencing. Fukunaga and Doudna now show that SGS3 is an RNA-binding protein that ...

The goal of this research project is to identify the specific RNA molecules these proteins bind, what that binding interface looks like, and to determine the role(s) of these interactions in ...