Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that ...

New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins ...

These TF-specific structural states may direct gene-specific regulatory events; in other words, Mediator—a general transcription factor—may acquire gene-specific functions that are triggered by TF ...

Research into transcription factors deepen understanding of the 'language' of the genome, offering insights into human development.

A deeper understanding of osteosarcoma , the most common primary malignant bone tumor affecting children and adolescents, is ...

Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Genes and Development 29: 48-62. Dai, Q, Andreu-Agullo C, Insolera R, Wong LC, Shi SH and Lai EC ...

Several transcription factors in developing neurons exhibit broad-to-restricted expression patterns, but the relevance of ...

The ongoing development of transcription factor-based drugs is a significant step toward effective, targeted therapies for MAFLD and MASH. The challenge remains in achieving long-term efficacy ...

The data convincingly show that the transcription factor Sp1 regulates ephrin-mediated axon guidance in the spinal cord. Although the authors show that Sp1 and its co-activators p300 and CBP are ...

Researchers have found a new role for the transcription factor (proteins that regulate the transcription, or copying, of genes). In the fruit fly, this transcription factor, named Traffic Jam, ...

Under normal circumstances, the dominant mouse would usually step forward while the subordinate mouse would retreat. “But when we put in our synthetic transcription factor, all bets were off, and the ...