Researchers from Northwestern University have stumbled upon a previously unobserved function of a protein found in the cell ...

Short conserved DNA sequences present at 10 and 35 bases upstream of the transcriptional start site promote the binding of the RNA polymerase holoenzyme complex and transcription is initiated on ...

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

Transcription factors are proteins involved in the process of converting, or transcribing, DNA into RNA. Transcription factors include a wide number of proteins, excluding RNA polymerase, that ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions ...

a multi-protein complex known to regulate transcription elongation. By targeting the BRD4-containing CDK9 complex in cultured cells, the scientists discovered that cell responses to oxygen ...