The researchers found that cells with reduced CHMP6 activity had “leakiness” in endolysosomal components that allowed tau seeds, or small fibrils, to escape endosomes and latch on to tau in the cell’s ...

Testing of the mice post mortem showed lowered levels of tau tangles and folds and fewer tau seeds. They also found the same results when applying their spray to human nerve tissue samples.

More information: Naoto Watamura et al, In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds, Nature Neuroscience (2024 ...

Figure 5: Age-dependent increase in insoluble tau in P301L (JNPL3) mouse brains. We have reported a transgenic mouse line, JNPL3, expressing human tau with the P301L mutation that develops NFT ...

A new study from Mass General Brigham researchers has found faster accumulation of tau-a key indicator of Alzheimer's disease-in the brains of women over the age of 70 who took menopausal hormone ...

TauRx Pharma's effort to bring a tau-targeting drug for Alzheimer's disease (AD) to market has been a marathon, with a number of setbacks over the years, but the company reckons it may finally be ...