recognizes the PKA-dependent phosphorylation of ser409 in tau; immunoreactivity with neurofibrillary pathology in both early and advanced Alzheimer’s disease, but not in normal brain tissue; reacts ...

More information: Jiyoen Kim et al, TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model, Nature Neuroscience (2024). DOI: 10.1038/s41593-024-01777-2 ...

This news may put some minds at ease. “Our test identifies very early stages of tau tangle formation — up to a decade before any tau clumps can show up on a brain scan,” said senior study ...

Conversely, phosphorylation sites outside the STA core—serine-202, threonine-205 (both recognized by AT8), and threonine-231—marked a broader range of tau aggregates, including precursor and ...

The results of a new study show that suppressing KCTD20, which responds to the neurotransmitter glutamate, activates a mechanism for expelling tau proteins.