In a study published in the Journal of the American Chemical Society, scientists explore how a brain protein called tau changes its behavior when a small chemical group called a phosphate attaches to ...

Three kinases have been strongly linked to the aberrant phosphorylation of tau, cyclin-dependent kinase 5 (CDK5), glycogen synthase kinase 3β (GSK3β) and extracellular signal-regulated kinase 2 ...

Tau hyperphosphorylation and conformational changes in the brain parenchyma start around seven months. Tangle-like pathology is mainly observed in the brain stem and spinal cord, and to a lesser ...