Amyloid precursor protein (APP) plays a central ... Here we describe the 1.8 Å resolution crystal structure of the N-terminal, heparin-binding domain of APP (residues 28–123), which is ...

Figure 1: Epididymal and testicular histology in Tarbp2-/-mice. Figure 3: In situ hybridization and immunohistochemistry of GH1, Tnp2 and Prm2. For histological evaluation, we fixed dissected ...

Alternative splicing (AS) of pre-mRNA plays a crucial role in tissue-specific gene regulation, with disease implications due to splicing defects. Predicting and manipulating AS can therefore uncover ...

Their study, published in Nature Cell Biology, shows that a protein called Serrate connects RNA modification and microRNA production, two essential cellular functions, in a way previously unknown.