The process of splicing is concurrent with mRNA transcription, with possible splicing regulatory roles for factors involved in chromatin structure, transcription, and other steps (Nilsen ...

Alternative splicing is a molecular mechanism that modifies pre-mRNA constructs prior to translation.This process can produce a diversity of mRNAs from a single gene by arranging coding sequences ...

Professor Vlad Pena's group focuses on the structural basis of human pre-mRNA processing under normal, pathological and drug-induced conditions. Our group focuses on the structural basis of human ...

Alternative splicing enables a single gene to encode multiple mRNA variants and, consequently, diversifies protein isoform products. The advent of deep sequencing technologies has revealed that 95 ...

The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed into mRNA precursors, is correctly assembled into mature mRNA. Splicing ...

EMBL Grenoble Group Leader Wojciech Galej, who has been working on pre-mRNA splicing machinery for more than 15 years, first decided to focus on the minor spliceosome seven years ago -- a project ...

My lab studies mRNA splicing mechanisms, its dysregulation in cancer and genetic diseases, and the development of RNA-targeted therapeutics.

RNA splicing ribozymes have been shown to possess a conserved active site that can engage small molecules, opening possibilities for the control of gene expression. genprowebdirectory ...

The combined results of their research, including work in mouse models, indicated that the effects of TREs interfere with a critical process called gene splicing, which is essential for gene function.

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...