How can only 25,000-30,000 protein-coding genes in humans produce the massive variety of proteins, cells, and tissues that exist in our bodies? The answer: alternative splicing. A critical finding ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...

A complex molecular machine, the spliceosome, ensures that the genetic information from the genome, after being transcribed ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

More information: Prashant Bhat et al, Genome organization around nuclear speckles drives mRNA splicing efficiency, Nature (2024). DOI: 10.1038/s41586-024-07429-6 Provided by California Institute ...

The idea that speckles might be storage sites for spliceosomes triggered Guttman to look deeper into how nuclear organization might affect the splicing process. In a recent article, he showed that ...

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Alternative splicing (AS), a ...

The 5 mg risdiplam tablet provides the same efficacy and safety for spinal muscular atrophy as the currently available oral ...