RNA splicing is a cellular process that is critical for gene expression. After genes are copied from DNA into messenger RNA, ...

It was known that the spliceosome has quality control mechanisms, but the mechanistic details were not understood. For their experiments, the Heidelberg researchers led by BZH director Prof. Dr.

How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as ...

We study minor spliceosome which is a parallel pre-mRNA splicing machinery in the cells of most metazoan organisms. Our main aim is to investigate mechanism and regulation of this nuclear machinery, ...

What's the difference between mRNA and pre-mRNA? It's all about splicing of introns. See how one RNA sequence can exist in nearly 40,000 different forms. Next, the snRNPs U2 and U4/U6 appear to ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

The spliceosome then converts them into mature ... Dr Irmgard Sinning used the fission yeast Schizosaccharomyces pombe, a model organism frequently used in cell biology. Using molecular markers ...