Intestinal stem cells are multipotent adult stem cells, which in mammals reside in the base of the crypts of the adult intestine. Intestinal stem cells continuously self-renew by dividing and ...

Cell biology revolves around a crucial concept: cells require nutrients for their survival, just as our bodies rely on nutrition (food) to support proper tissue and overall organismal functions. This ...

引言在与结直肠癌（colorectal cancer, CRC）的抗争中，研究人员发现了一个令人困惑的现象：即便精准清除表面标志物LGR5+的癌症干细胞（cancer stem cells, CSCs），肿瘤仍会死灰复燃。2月10日Nature ...

I don't necessarily think about normal stem cells dying when colon cancer is starting,” Sethi commented. To understand the sequence of these early events, the researchers did a timed deletion of one ...

Background Treatment strategies for Crohn’s disease (CD) suppress diverse inflammatory pathways but many patients remain ...

New research in eGastroenterology identifies the unfolded protein response (UPR) as a crucial mechanism in maintaining ...

Exposure of intestinal stem cells to toxic insults might never lead ... the steps leading to inflammatory bowel disease and cancer. Direct comparison of multiple samples collected from an ...

By comparing young and aged mouse intestinal tissues, the researchers uncovered critical insights into the interplay between these signaling pathways in supporting stem cell maintenance over time.

The novel drug CT-179 ... How Healthy Stem Cells Turn Into Oral Cancer Feb. 4, 2025 — Researchers have identified the molecular and cellular mechanisms that transform healthy stem cells into ...

TW: For the last 17 years, the intestinal stem cell field has assumed that Lgr5 ... therapeutics that can prevent the development of cancer. That's why it's so critical to understand what cell ...

The microbiota composition is altered in colorectal cancer (CRC) and inflammatory bowel disease. Intestinal bacteria affect intestinal stem cell homeostasis in Drosophilaand mice. Toll-like ...