Hypomethylation on fibroblast growth factor receptor 2 (FGFR2), a receptor tyrosine kinase (RTK) oncogene, increased transcript and protein abundance and drove cancer activity. Genetic mutations in ...
Ephs may behave in a similar manner to oncogenes or tumor suppressors [52] in different settings. Silencing of Ephs in malignancy or the expression of Eph RTK without ephrin binding and hence ...
I study and characterize the response to KRAS G12C, SOS1 and SHP2 inhibitors alone or in combination with receptor tyrosine kinase (RTK) or MEK inhibitors in different tumor types to determine the ...
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